Portfolio overview

HealthSage AI

HealthSage AI is dedicated to transforming healthcare delivery and patient pathways by harnessing the power of generative Artificial Intelligence (AI), and by collaborating with healthcare partners and innovators. HealthSage AI created a vertical end-to-end platform for open-source AI development in healthcare and is founded on the principles of: Always Open, Always Responsible, and Always Safe.

HealthSage AI

Branch: HealthTech

HealthSage AI

The impact of generative AI

In the EU, healthcare costs exceed €1.2 trillion annually, with €90 billion attributed to administrative expenses. Healthcare professionals spend 8.7 hours per week (more than 1 workday a week!) on administrative tasks, while crucial medical knowledge remains buried in unstructured data.

However, with the rise of AI, particularly Large Language Models (LLMs) and generative AI, significant improvements in patient outcomes and overall care quality are anticipated. AI has the potential to streamline administrative processes, unlock valuable insights from data, and revolutionize healthcare practices, leading to a more efficient and patient-centric approach.

For HealthSage AI we track the impact targets:

➡️
Time savings (in hours) of healthcare providers
➡️
Customer satisfaction metric of healthcare providers

SDG Alignment

Transform healthcare delivery

Providing an open, secure, and regulatory-compliant platform, HealthSage offers the healthcare industry a trusted and transparent foundation for numerous AI applications. For example, applications that create problem lists, offering healthcare professionals a concise overview of a patient’s health issues. Or AI-solutions that simplify administrative duties, such as the creation of discharge letters. Additionally, applications that support clinical decision-making, helping healthcare professionals to deliver the best care by automatically leveraging structured data. And last, but not least: applications that has the capability to transform complex clinical notes into language that is easily understandable for patients, enhancing clarity in communication.

HealthSage AI is founded by Harm-Jan Wessels (CEO) and Marcel Alberti (COO). Harm-Jan is a serial entrepreneur in the healthcare and software industry. He has built two international businesses acquired by General Electric (Applicare) and Philips (Forcare). Marcel is an expert in digital transformation.

Meet the HealthSage Team

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OpenUp

Mental health accessible to all

Mental health issues are a pressing and growing challenge to our society, affecting about 25% of the European population every year. The solutions however, remain largely inaccessible due to an overloaded healthcare system. Until now.

OpenUp enables employers to give their employees direct, fast and easy access to certified psychologists and online tools to improve mental wellbeing through a fully digital web/app platform. iPractice is a ‘regular’ psychological practice that provides blended psychological care services, which means that online & chat support is interspersed with offline contact with a certified psychologist.

 

For OpenUp we track the impact targets:

➡️
Cumulative number of unique OpenUp user sessions
➡️
The blended score of NPS score of users of 1-1 sessions and group (Spaces) session with a score of higher than 8

SDG Alignment

Democratising mental health support

As of today, OpenUp serves more than 550 employers reaching over 150.000 employees (from leadership teams to blue collar workers) across the Netherlands, Germany and France. We believe OpenUp is democratising mental health support. With their strong founder team, growth track-record and this latest round of growth capital OpenUp can reach many more people in need and create systemic impact.

The OpenUp Group is founded by two serial entrepreneurs Gijs Coppens, an engineer and cleantech entrepreneur (and practising psychologist!) and Floris Rost van Tonningen, founder of ao IEX, Hyves en soople. The OpenUp Management team also consists of Bertien Dumas, a licensed doctor and former strategy consultant who leads iPractice and CFO Rik Plender, a former BCG consultant who helped build OpenUp from the start.

Meet the OpenUp Team

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Incision

Using technology to improve surgical care

Surgical outcomes vary wildly based on location, access to training, and consistency of execution. Errors, protocol drift, and fragmented workflows lead to unnecessary complications. Meanwhile, Sterile Processing Departments (“SPD”) operate under intense scrutiny and regulation yet often lack scalable, up-to-date training and tracking systems.

For Incision we track the following impact target:

➡️
The cumulative number of reductions in surgical complications

SDG Alignment

Unify surgical education with daily execution.

Founded in 2014 in Amsterdam by Prof. Theo Wiggers and a team of healthcare visionaries, Incision originally built Incision Academy, a rich library of 3D procedural videos, accredited courses, and role-based learning content for the OR.

Today, Incision pushes further, embedding knowledge where it matters, and in the clinical flow.

    • Incision Assist turns static protocols into dynamic, surgeon-specific, case-ready guides. Teams access setup, materials, workflow, updates in one application, improving preparation, reducing variance, and speeding onboarding.
    • Incision MySPD offers SPD staff a structured, continuously updated training and competency tracking platform, helping departments stay audit-ready and safe in practice.

Together, they unify surgical education with daily execution

Track record

  • Trusted by leading hospitals, healthcare systems and educational institutes globally (500K+ users in 30+ countries and at 350+ institutes)
  • Hospitals using Incision’s products report improvements in team alignment, case prep, and OR efficiency metrics (90% increase in staff knowledge, 40% reduction in error rates, $500K/year in cost reductions due to OR errors)
  • Incision has formed various partnerships with leading institutions such as Tanner Health and Caresyntax to combine real-time knowledge delivery with advanced performance analytics

We believe surgical care is a frontier where technology and education can literally save lives. Incision is not just creating content: it’s embedding decision intelligence in the OR and SPD departments. That’s a step-change. By enabling teams to do better, consistently, Incision helps reduce variation and accelerates safer surgical scaling in emerging and developed systems alike.

Meet the Incision Team

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SkinVision

Instant insights in potential melanoma

The technology analyzes your photo and gives you an instant risk assessment and advice on what you should do next, so that you can see a doctor in time if needed.

The app is offered through insurance companies, employers (organizations) and directly to the consumer market. The company was founded in 2011 and has a solid history of technology development by a team of highly regarded dermatologists and machine learning engineers, and has over 1.2 million users worldwide, with more than 3.5 million photos taken and over 40,000 skin cancers found.

For SkinVision we track the following impact target:

➡️
Number of skin assessments

SDG Alignment

A more efficient health care system

Research proves that SkinVision’s CE marked, clinically validated algorithm can detect 95% of skin cancer. The sensitivity of general practitioners ranges from 61% and 66%, while the sensitivity of dermatologists is between 75% and 92%. As 1 out of 5 people will develop skin cancer and early detection is key to survival, the technology forms a strategic compliment to doctors to detect skin cancer as soon as possible. It prevents unnecessary late treatment, empowers patients and leads to a more efficient health care system.

At Rubio, we are super excited about this investment: we firmly believe technology is a strategic compliment to doctors to provide better healthcare, lower costs to the system and empower millions consumers worldwide to live healthy lifestyles: SkinVision is such an example. Erik and his team are on track to be the international leader in AI-enabled dermatological solutions and we are thrilled to be part of the adventure.

Meet the SkinVision Team

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Everyone.org

A universal healthcare platform that puts patients first

The mission of Everyone,org is to create better health and wellbeing for everyone — regardless of where they live. They provide global access to newly approved medicines which are otherwise not available to patients.

There is currently no global, harmonized system for approval of medicines and this leads to delays that cause needless suffering and deaths. Delays are largely due to bureaucracy and extensive administration needed by big pharma companies.

Everyone,org actively works to bridge the gap between approval and availability for patients, doctors and hospitals who need it most, primarily for life-threatening and debilitating illnesses. In addition to global accessibility, Everyone,org has a strong focus on improving the affordability of highly priced medicines.

For Everyone.org we track the following impact targets:

➡️
Number of people helped by giving medical information (50%)
➡️
Number of patients supplied with medication (50%)

SDG Alignment

Reaching patients worldwide

Their network extends to more than 60 countries. As a licensed medicines intermediary, TheSocialMedwork provides a unique service, with a 100% quality rating from doctors and patients who actively use the service. The company was founded by a deeply committed and experienced team in the field of tech and healthcare; Sjaak Vink (co-founder of MyTomorrows), Jamie Heywood (co-founder of PatientsLikeMe), and Bernard Muller (co-founder of Treeway and Project MINe).

The growth capital provided by Rubio will support Everyone,org to scale their platform and expand their reach to more patients worldwide, tracking both patient awareness, access to medicines and affordability as impact indicators. This is closely aligned with the UN’s Sustainable Development Goals #3: to ensure healthy lives and promote well-being for people all at all ages.